To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)
CONCLUSION Although more research and consensus are needed to determine the optimal length of time for holding GLP-1 receptor agonists before a procedure requiring anesthesia, it is important for practitioners and patients to be aware of the increased risks for aspiration and to consider strategies to mitigate harm
Physiol Rev 87(4):14091439 Holst JJ (2019) Long-acting glucagon-like peptide-1 receptor agoniststatus December 2018
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