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The best maintenance dose of ipamorelin depends heavily on research objectives
Ipamorelin's GHSR-1a mechanism is additive to GHRH-pathway stimulation because the two receptor systems converge on different intracellular signaling pathways (Gs-cAMP for GHRHR, Gq-PKC and MAPK for GHSR-1a) and can both stimulate somatotroph GH release simultaneously
Therefore, the two peptides may be used to provide a rapid onset of action with Ipamorelin and prolonged effects with CJC-1295
combining the two produces additive or synergistic IGF-1 induction, a finding relevant to understanding dual-axis hepatic stimulation