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doi: 10.1172/JCI98747

Spatial transcriptomics combined with single-cell RNA sequencing identified high expression levels of ferroptosis-related genes, including TFRC, NCO4, and SLC3A2, in granulosa cells of patients with ovarian senescence, while GPX4 expression was notably low ( BNC1 mutations that lead to premature follicular activation and atresia (Zhang et al., 2018)