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Instead, therapeutic modulation of GSH must be tailored to disease context, reflecting the fundamental GSH paradox: whereas cancer therapy often seeks to deplete elevated GSH to induce oxidative stress and cell death, neurodegenerative and inflammatory diseases may require restoration of GSH homeostasis

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, 68 , 1184-1192, doi: Liu, Y., Liu, T., Lei, T., Zhang, D., Du, S., Girani, L., Qi, D., Lin, C., Tong, R., and Wang Y

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Clinical testing of IGF-IR-targeted agents The identification of IGF-IR as an important cancer-promoting protein has stimulated the development of many IGF-IR-targeted agents, including anti-IGF-IR mAbs and small-molecule inhibitors