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4 Mode of action of SNAC in oral semaglutide: preclinical and early clinical studies The proposed mechanism of action of SNAC when co-formulated with semaglutide is shown in Fig

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Downregulating the expression of miR-23a and increasing the expression of the mitochondrial protective gene peroxisome proliferators-activated receptor- coactivator-1 (PGC-1) can exert an anti-apoptotic effect on human hepatocytes [34]

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