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A Phase 2a trial in adults with metabolic dysfunction-associated steatotic liver disease (MASLD, a fat-related liver condition formerly called NAFLD) found that retatrutide reduced liver fat content by more than 80% at 48 weeks at the higher doses, with a meaningful share of patients reaching normal liver-fat levels

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9,13 Two patients had bladder diverticula complicated by spontaneous bladder rupture, and two other patients (P1 and P2 in this study) developed rectal prolapse with profuse anal bleeding during puberty

Model performance was evaluated using cross-validated area under the receiver operating characteristic curve (AUROC)

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