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This approach is particularly valuable for drugs that require high fat-solubility for efficacy, such as certain anti-cancer agents or drugs targeting metabolic disorders [5, 17, 19]

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Moreover, pediatric MASLD is associated with T2DM, cardiovascular metabolism, and renal risk, 157 indicating that GLP-1RA can act as a metabolic modifier, thereby improving prognosis, especially in patients who have difficulty adhering to lifestyle changes

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Ferenci P, Stremmel W, Czlonkowska A, Szalay F, Viveiros A, Stttermayer AF, et al