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[20] have demonstrated that zinc plasma levels are inversely correlated with glycemic status (HbA1C) in diabetes mellitus, while in patients with MS an association between high zinc concentration in urine (zincuria) and fasting glucose level, glycated hemoglobin level, insulin resistance, and also CRP were found

While mtROS generation serves as a signaling cue for immune activation, excessive accumulation leads to oxidative stress, mtDNA damage, and mitochondrial permeability transition

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Serine also restricts aberrant cytokine secretion by macrophages [111], promoting mitochondrial homeostasis, controlling oxidative stress and inflammation in aged mice [112], possibly suppressing tumorigenesis during senescence

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