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Slower gastric emptying increases the likelihood that a large, rich, or acidic meal will sit in the stomach longer, and when that is combined with foods or behaviors that relax the lower oesophageal sphincter, reflux becomes more likely and more noticeable

It stores and releases bile, which is needed to break down fats in the food you eat

At 20 years, levels average around 200 ng/ml, while studies document concentrations drop to approximately 80 ng/ml by age 60[2]

In addition, berberine can induce activation of PI3K/AKT signaling pathway, which is related to Nrf2 expression and neuroprotection (Zhang et al., 2017)

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