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[27] [29] Attempts to bypass that issue by infusing patients in clinical tests with very high doses of GLP-1in order to overcome its rapid metabolism in the bloodstreamhad produced extremely severe nausea, followed by immediate vomiting

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They follow predictable patterns that correlate with dose tier, escalation speed, and individual tolerance

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Employers are asking, "Can I continue to manage these costs?" Brown said

This study adds a new dimension to the risk-benefit assessment of GLP-1 RAs, highlighting the importance of long-term pharmacovigilance in diabetes care