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Alternatively, creatine supplementation might modulate the bioavailability of Hcy for the remethylation and trans-sulfuration processes, in turn influencing GSH synthesis, and affecting the redox status of the cells

The sigma class of cGSTs is also related to these processes, particularly the detoxification of xenobiotics and peroxides due to glutathione-dependent peroxidase activity, as well as immunomodulation of the immune response through the synthesis of prostaglandins [1214]

Patients with depression history need careful monitoring

, 37 , 211-228, Rao, A., Jericho, H., Patton, T., Sriram, S., Hebert, T., et al