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540 Iron homeostasis in the central nervous system is influenced not only by systemic iron metabolism, but also by function of the blood-brain barrier (BBB)

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And this is, incidentally, exactly how NSAIDs like ibuprofen reduce inflammation, by acting on this COX-2 pathway

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Shen Y, Mao H, Huang M, Chen L, Chen J, Cai Z, Wang Y, Xu N (2016) Long noncoding RNA and mRNA expression profiles in the thyroid gland of two phenotypically extreme pig breeds using ribo-zero RNA sequencing