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In some animal studies, increased flavonoid intake has been inversely associated with the development of atherosclerosis ( Saponins (glycosidic metabolites from TCM botanical drugs like Panax notoginseng ) likewise display broad anti-atherosclerotic effects

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Reducing LGG or butyrate diminished Treg counts and eliminated the pro-osteogenic effects

But these were typically transient and subsided when the body adapted to the higher doses

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