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These are obviously helping patients a lot, but what are the things that we should be looking at? Horneff said

Additionally, most mechanistic studies rely on animal models, raising concerns about translatability to humans due to interspecies differences in GLP-1R distribution and signaling (Drucker, 2022)

Another possibility is that retinal or vitreous hemorrhage increases iron accumulation in patients with proliferative DR

(5) Omega-3 Omega-3 fatty acids from fish oil have been shown to significantly reduce blood pressure (a risk factor for CKD) in several clinical trials on patients with hypertension (6)

[DOI] [PubMed] [Google Scholar] 306.Collini P, Noursadeghi M, Sabroe I, Miller RF, Dockrell DH

As GLP-1 has been implicated as a mediator in the putative gutrenal axis (a rapid-acting feed-forward loop that regulates postprandial fluid and electrolyte homeostasis), direct actions on the kidney have been proposed