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The key anti-oxidative transcription factor, nuclear factor E2 related factor 2 (Nrf2 or NFE2L2), plays a dominant role in defense machinery by reprogramming the iron, intermediate, and glutathione peroxidase 4 (GPX4)-related network and the antioxidant system to attenuate ferroptosis

Proper hygiene and sterile techniques can minimize this risk

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It has potent effects of antioxidant, anti-inflammatory, anti-angiogenesis, and anti-cancer [131]

A: Visible changes can occur after the first use, with more significant results typically observed within a few days to weeks of consistent use