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Gut microbiota contribute to MASLD development through various mechanisms, including disruption of liver choline metabolism (necessary for VLDL synthesis and liver lipid export) (150), alterations in bile acid synthesis (151, 152), ethanol production (153), and increased lipopolysaccharides (LPS), which results in liver inflammation (154156)

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doi: 10.1042/EBC20200018 63

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Antioxidants (Basel) 10(11):1775 Wirthgen E et al (2017) Kynurenic acid: the Janus-faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions

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Yet, the structural determinants that differentiate the two modes of transport of GSH by MRP1, and in particular the regions specific of the stimulated mode, remain largely unknown

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Vaccination (HBeAg): indicator Indicator Methods for assessing flow through a system by injection of a known quantity of an indicator, such as a dye, radionuclide, or chilled liquid, into the system and monitoring its concentration over time at a specific point in the system

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