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However, in a chronic model based on cuprizone treatment associated with rapamycin to inhibit OPC differentiation so as to improve reproduction of the characteristics of chronic MS, remyelination was faster and more robust in the cortex than in the CC (Bai et al., Subventricular Zone-Derived Neural Progenitors Evidence for Subventricular Zone-Derived Oligodendrogenesis In the adult brain, the wall of the lateral ventricle is a stem cell niche with a unique cellular and extracellular organization (Mirzadeh et al., 2008