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Macular sensitivity was measured with the Macular Integrity Assessment microperimetry instrument, which measures sensitivity at 68 loci and calculates the mean sensitivity from those 68 measurements

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The transepithelial potential difference was clamped to 0 mV using a DVC 1000 amplifier (WPI, Sarasota, FL, USA) and the resulting short-circuit current was recorded through Ag-AgCl electrodes and 3 mol l 1 KCl agarose bridges

For a deeper dive into the studies, go to the original article on CREATINE.

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2.10.2 Data analysis and data processing The sequences obtained were analyzed using the bioinformatics platform QIIME2 version 2020.6