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Large clinical trials such as the STEP 1 trial demonstrated no increased thyroid cancer incidence over 68 weeks

With over 600 E3 ligases in humanscompared to only 2 E1s and 38 E2sthey represent the most specific step in the ubiquitin-proteasome system, playing essential roles in processes such as protein degradation, intracellular signaling, and transcriptional regulation (Zhao and Sun, 2013

This analysis was performed on (I) a sample of healthy RBCs, (II) hardened RBCs treated with different concentrations of GA (0.01% and 0.02%) to assess deformability, and (III) RBC samples from patients with sickle cell anemia disease

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