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Genes 12 , 1437 (2021)
Dosing & Half-Life: Sermorelins drawback is its very short half-life (about 1020 minutes in circulation)
These medications are expensive
Olpasiran and lepodisiran are GalNAc conjugates containing siRNAs that target the LPA gene, promoting RISC-mediated degradation of Apo(a) mRNA and preventing Lp(a) particle assembly in hepatocytes
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