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PMID: 111 Gholizadeh ShamasbiSDehganPMohammad-Alizadeh CharandabiSAliasgarzadehAMirghafourvandM

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Epilepsia 51 , 883890 (2010)

the object of this invention is to provide a preparation method of high-purity L-carnitine, which is characterized in that to prepare L-carnitine with a purity being above 97%, wherein the content of D-carnitine is below 2%, by detecting and controlling the content of chiral material and chiral intermediate during the whole synthetic process which is started from S-epichlorohydrin, wherein the method include the following steps: the present invention provide a optically pure compound of formula (II) wherein R represents methyl, ethyl, isopropyl, butyl or benzyl, and X represents Cl or Br