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Because of these conflicting findings, the following middle ground has been proposed for using vitamin D to treat SLE: a) patients with SLE that have 25-hydroxyvitamin D 2 plus 25-hydroxyvitamin D 3 serum levels less than 30 ng/ml should be treated with vitamin D to keep these levels at or above 30 ng/ml or, in patients having major SLE-related organ involvement, at 36 to 40 ng/ml and b) patients with 25-hydroxyvitamin D 2 plus 25-hydroxyvitamin D 3 levels at or above 30 ng/ml should not be treated with vitamin D unless they have major SLE-related organ involvement in which case they should be treated with 25-hydroxyvitamin D 2 plus 25-hydroxyvitamin D 3 to maintain their serum vitamin D levels between 36 and 40 ng/ml

Peripheral CD4 + T cell populations are reduced, whereas the suppressive activity of CD4 + FOXP3 + Tregs is augmented (Rosenkranz et al., 2007)

Common Side Effects Injection site reactions represent the most frequently reported effects

Kim, W., Shin, Y.-K., Kim, B.-J

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