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Mechanistically, GHK-Cu preserved mitochondrial function by increasing mitochondrial membrane potential, alleviating age-related mitochondrial network fragmentation, shifting mitochondrial dynamics toward fusion via regulating drp-1 and fzo-1 expression, and promoting ATP biosynthesis

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Polyamines, such as putrescine, spermidine, and spermine, are critical metabolites derived from arginine via ornithine decarboxylase but not directly from L-citrulline [49]

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