SIRT1 through interaction with heat shock protein A4 (HSPA4) represses the expression of pro-inflammatory cytokines
The peptide down-regulated oxidative phosphorylation, suppressed MYC target genes, and attenuated PI3K-AKT-mTOR signalingpathways classically inhibited in validated lifespan-extending interventions
Approaches to past research include analyzing the aqueous humor, which is thought to be a useful way to discover specific molecules that contribute to glaucoma pathophysiology, and a proteomic approach, which has been used to identify proteins that are candidates for making prognoses in glaucoma pathogenesis
Such findings suggest that MOTS-c might play a contributing role in healthy aging, especially in maintaining metabolic function and physical performance as organisms get older
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10.22038/ijbms.2023.68487.14937 76 MullinsP