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Nrf2 is a transcription factor that promotes the expression of a wide array of cytoprotective and detoxifying genes (Figure 3) (Zhang et al., 2022

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High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

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166 Third, GSK3 is activated in the AD brain, and the hyperphosphorylation of tau protein in AD patients is mediated by GSK-3

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