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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
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Meanwhile, the diffraction peaks in Figure 2E according to the selected electron diffraction (SAED) characterization correspond to (220), (200), and (111) crystallographic planes, which are consistent with the crystallographic planes in the powder diffraction card of AgNPs, so the prepared ones are silver nanoparticles
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