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Rather than being driven by cardiomyocyte loss and impaired systolic function, HFpEF develops in the context of systemic comorbiditiessuch as hypertension, T2DM, coronary artery disease (CAD), chronic kidney disease (CKD), anemia, AF, obesity, and pulmonary diseasethat contribute to a chronic low-grade inflammatory state

ROS inhibits STING dimerization by oxidizing Cysteine 147 on murine STING during MHV68 infection

McGeer PL, Itagaki S, Boyes BE, McGeer EG

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In contrast, studies on human senior subjects show that low IGF-1 levels are associated with poor knee extensor muscle strength, slow walking speed, and difficulty with mobility tasks [6]