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The current pipeline of investigational, muscle-preserving therapies comprises 32 assets, of which 47% are at preclinical stage, 22% in phase 1 and 31% in phase 2, as the most advanced candidates

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Having an oral GLP-1 therapy to help improve glycemic control was an innovation in and of itself, SOUL senior author John B

Available evidence from diabetes and obesity trials demonstrates substantial weight regain after discontinuation of GLP-1 RAs, reaching pre-treatment levels in some cohorts within 12-18 months of cessation, with accompanying deterioration in cardiometabolic parameters [72]