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pylori can effectively reduce CRC incidence (Butt et al., 2020)

C.Josep JulveJ

doi: 10.1089/ars.2017.7269

The evasion of immune surveillance by tumor cells involves the establishment of an immunosuppressive microenvironment through the secretion of metabolic byproducts and associated cytokines

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, et al

The acyl-coenzyme A (CoA) synthetase long-chain family (ACSL) located on the mitochondrial outer membrane and endoplasmic reticulum (ER) can catalyze the transformation of fatty acids to acyl-CoAs ( Studies conducted on the haploid cell line KBM7 through insertional mutagenesis indicate that the inactivation of LPCAT3 and ACSL4 allows cells to become resilient against RSL3 and ML162, two GPX4 inhibitors ( - ) and GPX4 are effective suppressors of ferroptosis, while ACSL4 and LPCAT3 are identified as pro-ferroptosis due to their role in incorporating PUFAs into membrane lipids