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The aggregation and denaturation that follow repeated freeze-thaw cycles will degrade both peptides, and unlike the lyophilized state, the damage is not reversible

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Label instructions for missed doses can differ between products, and taking double doses to make up for missed injections is dangerous

Liver function tests should be obtained at baseline, after 6-8 weeks during niacin dose titration, and periodically thereafter

Patients should be aware that sourcing unlicensed medicines from unregulated online suppliers is associated with significant risks, including counterfeit products, incorrect dosing, and lack of medical oversight

doi: 10.1038/s41467-019-11107-x 17 Cancer Genome Atlas N