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Visible improvement (8-12 weeks and beyond) For more stubborn types of skin discolourations, visible improvements can take 8 to 12 weeks or longer

A phenomenon called "estrogen withdrawal," which occurs in the late luteal phase of the menstrual cycle and is characterized by an abrupt decline in estrogen levels, is likely an important migraine trigger in some women (MacGregor 2009, Lay 2009)

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One-way ANOVA with post-hoc Tukeys test was employed to assess differences among the groups, while an independent t-test was used to compare two groups