Nausea Vomiting Heartburn Abdominal discomfort Diarrhea Constipation Bloating Indigestion Burping Fatigue Headache Mild redness, itching, or soreness at the injection site Less Common but Important Risks Gallbladder disease or gallstones requiring removal of gallbladder Delayed stomach emptying (gastroparesis) Pancreatitis Kidney Considerations Severe dehydration related to persistent vomiting or diarrhea may increase the risk of acute kidney injury
The only FDA-approved form of recombinant IGF-1 is mecasermin (Increlex), approved in 2005 exclusively for severe primary IGF-1 deficiency in pediatric patients
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This allows the molecule to stay intact until it reaches the absorption sites in the intestines
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These medications have seen an explosion in sales with the approval and off-label use for weight loss, typically resulting in a reduction in body weight of 15-21% when combined with nutrition and exercise