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10.1513/AnnalsATS.201701-065OC 75

doi: 10.1002/cbdv.200790152

Accordingly, the list of molecules which have been shown unequivocally to be physiological substrates of DPP-4 is short ( GLP-1 and GIP With regard to metabolic effects, the best characterized DPP-4 substrates are the two incretin hormones, GLP-1, and glucose-dependent insulinotropic polypeptide (GIP)

Loss of lean tissue, comprising skeletal muscle, bone, organs, and body water, is therefore an important consideration in patients undergoing weight reduction with GLP-1RAs

If lifestyle modifications prove insufficient, your GP may consider referring you to NHS Tier 2 or Tier 3 weight management services for additional support

doi: 10.1172/JCI142245 41 BrownRJAraujo-VilarDCheungPTDungerDGargAJackMet al