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The Globe and Mail reports that Ozempic's list price in Canada stands at $223 for a four-week supply, though patients often pay higher amounts depending on their specific dosage requirements

This is due to its ability to inhibit melanin production by influencing the enzyme tyrosinase

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References: Al-Temimi, A

Yaqun L, Haixia Y, Yuchen S et al (2022) An Shen Ding Zhi Ling ameliorates the symptoms of attention deficit hyperactivity disorder via modulating brain-derived neurotrophic factor-related signaling pathways

The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary