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We study the methionine cycle of the Reed-Nijhout model by developing a simple stylized model that captures its essential topology and whose kinetics are analytically tractable

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PI3K activates protein kinase B (Akt), which inactivates several important substrate proteins, such as glycogen synthase kinase 3 (GSK-3) 18 and forkhead box O, 19 and activates mammalian target of rapamycin (mTOR)