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However, high doses of vitamin B12, such as those used to treat a deficiency, might cause: Headache Nausea and vomiting Diarrhea Fatigue or weakness Its important to note that these side effects are generally mild and temporary

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This combination therapy has demonstrated promising therapeutic potential in prostate cancer and other types of tumors

TAMs release a number of angiogenesis-modulating molecules that include enzymes (COX-2, iNOS) [238], matrix metalloproteinases (MMPs-1, 2, 3, 9, and 12) [239], cathepsin proteases [240] and plasmin, urokinase plasminogen activator [241]