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Kidney and liver health play a role

The most common error isn't contamination

e.g., hematopoietic progenitors and renal tubules) compared with those tissues (e.g., liver) that only express the reduced folate carrier, which is universally expressed but has poor affinity for UMFA

The question courts have struggled with is whether a generic bearing a skinny label can be held liable for induced infringement if real-world prescribing patterns result in off-label use for the protected indication