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With just a little UV exposure, the release of a-Melanocyte Stimulating Hormone stimulates a natural increase in the production of melanin from the melanocytes in the skin

doi:10.1038/s41392-023-01481-w Neumaier F, Zlatopolskiy BD, Neumaier B

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Compounded medications are not reviewed by the FDA for safety, effectiveness or manufacturing quality in the same manner as FDA-approved drugs