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Our results indicate that GLP1R mutations in humans lead to defective cell surface expression and impaired activation of the cAMP pathway, resulting in major defects in insulin secretion

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Bosaeed M, Balkhy HH, Almaziad S, Aljami HA, Alhatmi H, Alanazi H, et al

327 In the inflammatory environment, the M1 to M2 shift promoted by GLP-1 is crucial for reducing the expression of inflammatory factors such as IL-6, TNF-, and iNOS