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Per the FDA guidelines, estimated treatment ratios for AUC 024h,SS and C max, 024h,SS were within the standard acceptance limits (0.80001.2500) and the critical bound upper 95% CI limits for both endpoints were 0

The groups were further subdivided based on whether they were taking semaglutide or a non-GLP-1 RA medication

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Currently does not cover obesity medications even with prior authorization

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Third, the assumption of comparability across trials may not fully account for differences in adherence, treatment intensification strategies, or background care, which could affect the magnitude of treatment effects