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[PubMed: 34324435] Systematic Review in Orthopaedic Sports Medicine (2025): A systematic review of 36 studies from an orthopaedic sports medicine perspective found that BPC-157 consistently enhanced growth hormone receptor expression and angiogenesis-related pathways while reducing inflammatory cytokines

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There is a plateau in treatment effect which could be due to balance between the up regulation of melanogenesis in the hyperpigmented area and the downregulation by niacinamide