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In addition to electronic database searches, manual searches were performed using Google Scholar, and the reference lists of all relevant primary and secondary sources were screened to identify additional eligible studies and gray literature

SCFAs stimulate the proliferation of colonic epithelial L cells and are bound to GPR43 above them, increasing intracytoplasmic calcium ion and cyclic adenosine cAMP concentrations and increasing GLP-1 secretion (Chambers et al., 2018

The GLP-1 receptor activation enhances insulin secretion, suppresses glucagon release, and slows gastric emptying, while GIP receptor stimulation further amplifies insulin response and promotes glucose uptake in peripheral tissues

These are usually mild and go away over time

The 2.5 mg dose is for initiation, but the remaining doses can be used for chronic weight management

Nature 404 , 661671, (2000)