In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) launched a review in July 2023 into the risk of suicidal thoughts and thoughts of self-harm associated with GLP-1 RAs, including exenatide, liraglutide, lixisenatide, dulaglutide and semaglutide
Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025
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The lack of normal distribution is likely due to the small sample size and high inter-individual variability typical in elite athletes
It is used to monitor gastrointestinal motility and as a secretagogue in the treatment of acromegaly
Just as Germanys AMNOG process demands rigorous proof of clinical value before new therapies reach patients, investors benefit from applying a similar lens to their own financial journeybalancing innovation with tested fundamentals