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Because AOD9604 does not stimulate IGF-1 production and lacks strong GH receptor agonism, it may present a safer alternative for long-term OA treatment [1]

doi: 10.1021/acs.accounts.5b00316

Tang J, Zeng C, Cox TM, Li C, Son YM, Cheon IS, et al

The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

Kazakova, K., et al

Change the location with every B12 injection to minimize inflammation and the risk of tissue damage