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When outcomes and utilization are managed together, the cost conversation shifts: one case study of a leading software company showed a projected 4.6x ROI and $2.8M savings when GLP-1 coverage is paired with behavior change programs

Kawano et al

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Conclusions Evidence accrued so far suggest that GLP-1RA could exert a modest renal benefit alongside CV protection, justifying its place as second-line drug in patients with T2D and CKD not achieving glycemic control with SGLT-2i and metformin according to KDIGO guidelines [87]

Addressing these gaps will facilitate precision medicine by enabling treatment strategies tailored to individual profiles [136], ultimately improving clinical outcomes (Table 2)