FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms
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Unfortunately, prostate cancer cells have significantly lower zinc levels, and hence they are unable to inhibit m-aconitase activity, ultimately resulting in the inability to obtain normal prostate fluid with citrate in tissue
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However, in some cases, they can persist for several weeks