In the phase 3 TRANSCEND-T2D-1 diabetes trial (537 adults with recent-onset type 2 diabetes), retatrutide reduced HbA1c by up to 2.0% and produced 16.8% weight loss at 40 weeks, with about 90% of participants reaching an HbA1c below 7%
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Understanding why 72 hours matters requires a brief look at what tirzepatide does inside your body after injection, and that story starts with a concept called half-life