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Clinical trials are designed around percent body weight reduction, achievement of predefined thresholds such as 10 or 15 percent loss, and improvements in obesity-related comorbidities

Arismendi E, Rivas E, Vidal J, et al

Biomed Pharmacother 83:212220 Zhou M, Ji S, Wu Z, Li Y, Zheng W, Zhou H, Chen T (2015) Synthesis of selenazolopyridine derivatives with capability to induce apoptosis in human breast carcinoma MCF-7 cells through scavenge of intracellular ROS

Mitochondrial ferritin protects bone cells from ferroptosis by reducing oxidative stress caused by excess ferrous ions, thus playing a protective role in bone health (14)

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[PubMed 10512094] 5