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The suggested dithiol mechanism for the reduction of EcRNR by EcGrx1 comprises a dithiol-disulfide exchange reaction followed by the stepwise reduction of EcGrx1(S 2 ) and EcGrx1(SSG) by two molecules of GSH (Fig

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N3 is the representative peptidomimetic inhibitor, and harbours a Michael acceptor as a warhead and substituents spanning all substrate-binding subsites

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[DOI] [PMC free article] [PubMed] [Google Scholar] 201.Bonaguidi M.A., Wheeler M.A., Shapiro J.S., Stadel R.P., Sun G.J., Ming G.L., Song H

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