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Direct binding of eNOS to the scaffolding domain of Cav-1 is a well-accepted mechanism to repress eNOS activity that is associated with endothelial dysfunction and cardiovascular disease 39,40

36,38,39 Compared to oral administration, whereby under 10% actually enters the blood stream, 52 orobuccal administration leads to over 80% absorption directly into the systemic circulation

Sonodynamic-nano synergistic therapy The fundamental principle of sonodynamic therapy (SDT) involves utilising ultrasound to stimulate sonosensitizers to activate cavitation activity and promote the generation of ROS, followed by inducing the apoptosis of harmful cells such as tumour cells and bacteria [150]

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Additionally, several conditions appear to frequently co-exist with CSU and appear to be linked by a common underlying pro-inflammatory state

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